Serum Thyrotropin (TSH) Levels after Recombinant Human TSH Injections in Children and Teenagers with Papillary Thyroid Cancer

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Serum thyrotropin (TSH) levels after recombinant human TSH injections in children and teenagers with papillary thyroid cancer.

CONTEXT In preparation for whole body radioactive iodine scanning, recombinant human TSH (rhTSH) is usually administered as 0.9-mg i.m. injections on 2 consecutive days without regard to age, body size, or other comorbid conditions. OBJECTIVE Our objective was to determine whether the usual adult rhTSH dosing regimen would result in excessive elevations of serum TSH in children and teenagers ...

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Effects of Acute Recombinant Human TSH on Serum Ghrelin Levels

UNLABELLED Recent findings showed the presence of a reciprocal relationship between thyroid hormones and ghrelin, although the exact mechanism is not known. DESIGN Our study is addressed to evaluate the effect of acute exogenous rhTSH administration on serum ghrelin levels in athyreotic patients on replacement l-thyroxine therapy. The study group included 50 patients (16 males and 34 females)...

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Serum TSH measurement in children with thyroid disorders.

A number of thyroid function tests have recently been developed in which components of the hypothalamic-pituitary-thyroid axis are directly measured; these include estimation of the total concentrations of the thyroid hormones, thyroxine (T4) and tri-iodothyronine (T3), their free (unbound) fractions, the thyroid hormone-binding proteins, and the serum TSH (thyroid-stimulating hormone, thyrotro...

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Detection of Polyethylene Glycol Thyrotropin (TSH) Precipitable Percentage (Macro-TSH) in Patients with a History of Thyroid Cancer

BACKGROUND Owing to its large molecular size, polyethylene glycol (PEG)-precipitable thyrotropin (TSH) can accumulate in the circulation, elevating TSH levels. PEG-precipitable TSH can be used to detect macro-TSH (mTSH) in serum. Our aim was to evaluate the prevalence of mTSH in patients who had undergone thyroidectomy for thyroid cancer. METHODS Seventy-three thyroid cancer patients and 24 c...

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The association between serum TSH concentration and thyroid cancer.

There is mounting evidence that the serum concentration of TSH is an independent predictor for the diagnosis of thyroid malignancy in patients with nodular thyroid disease. Furthermore, preoperative serum TSH concentrations are higher in patients with more aggressive tumours, suggesting a potential role for TSH in the progression of differentiated thyroid cancer. Based on these observations, pa...

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ژورنال

عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism

سال: 2005

ISSN: 0021-972X,1945-7197

DOI: 10.1210/jc.2005-1550